What is an effect of exposing mannitol to excessive cold?

When mannitol is exposed to excessive cold, it can undergo crystallization. Mannitol is a type of sugar alcohol that is often used as a diuretic and in pharmaceutical formulations. At lower temperatures, the solubility of mannitol decreases, leading to the formation of crystals. This crystallization can affect the stability and usability of mannitol in medicinal preparations, as crystallized material may not dissolve properly back into solution when needed. Understanding this property is essential for ensuring that mannitol is stored and handled appropriately in a pharmacy setting to maintain its efficacy and stability.