What is the beyond-use date for a non-sterile, semisolid preparation containing water, according to the U.S. Pharmacopeia (USP)?

The beyond-use date for a non-sterile, semisolid preparation containing water, according to the U.S. Pharmacopeia (USP), is a maximum of 30 days from the date compounded. This guideline is important for ensuring the safety and efficacy of the compounded preparation.

Semisolid preparations that contain water are more susceptible to microbial growth and degradation than those that do not. Therefore, the USP recommends a shorter beyond-use date to minimize the risk of contamination and to ensure that the product maintains its intended potency and quality.

Setting the beyond-use date at 30 days helps to balance the need for product stability with patient safety, allowing for a reasonable amount of time for use while safeguarding against the risks associated with microbial contamination and degradation of active ingredients over time. This standard aligns with the guidelines for the handling and storage of compounded preparations, ensuring that pharmacy technicians and pharmacists can provide high-quality and safe products to patients.