What is the goal of levigation in pharmaceutical compounding?

Levigation is a process used in pharmaceutical compounding primarily to reduce the particle size of solid substances. This technique involves the use of a small amount of liquid, often a non-solvent or ointment base, in which the powder is mixed and ground down to achieve a smoother and finer consistency. By reducing the particle size, the surface area of the substance increases, which can enhance its therapeutic properties, such as improving its bioavailability when administered.

While reducing particle size is the primary goal of levigation, it can also contribute indirectly to enhancing solubility and creating more uniform emulsions in subsequent formulations. However, the main purpose remains focused on the reduction of particle size to ensure proper mixing and incorporation into final preparations.