What is the proper beyond-use date for compounded oral solutions containing high water content?

The proper beyond-use date for compounded oral solutions that have high water content is 30 days. This timeframe is established based on the potential for microbial growth in solutions that contain significant amounts of water, which can encourage the proliferation of bacteria and fungi. Due to this risk, the short shelf life of 30 days ensures that the compounded solution is used while still maintaining its safety and efficacy.

Oral solutions with high water content are typically subject to stricter regulations regarding their stability and sterility. This is why, compared to solid dosage forms or solutions with lower water activity, a shorter beyond-use date is warranted. It takes into account both the degradation of active ingredients over time and the safety concerns associated with microbial contamination.